Population Genetics by Gillespie John H

Author:Gillespie, John H. [Gillespie, John H.]
Language: eng
Format: mobi
Publisher: Johns Hopkins University Press
Published: 2004-06-27T16:00:00+00:00

For a new mutation, q = 1/(2N), and small s we have

In very large populations, large enough that 2Ns ≫ 1, the probability of fixation of a deleterious allele becomes very small. However, when 2Ns is close to or less than one, the fixation of deleterious alleles can occur with reasonable probability. An unexpected application of this observation is in molecular evolution, as will be discussed in the next section.

When the effective size of the population does not equal the actual size, Ne ≠ N, the probability of fixation of a new advantageous mutation when h = 1/2 becomes

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